[논문] 다이어트가 통증도 감소시킨다!

2003.12.3 온라인 발행된 미국신경과학회지에 실린 논문에 의하면 다이어트가 통증을 억제하는 데 도움이 될 수 있음이 보고되었습니다.

통증을 억제하는 체내의 물질(k-opioid)의 생성이 식이제한에 의하여 증가하였고, 통증에 의한 반응도 줄여준다는 사실이 동물실험을 통해 나타났습니다.

아래는 이 논문의 영문 초록입니다.

목동경희한의원

Analgesia Induced by Dietary Restriction Is Mediated by the -Opioid System

Mercedes de los Santos-Arteaga, Sergio A. Sierra-Domínguez, German H. Fontanella, José M. Delgado-García, and Ángel M. Carrión

División de Neurociencias, Universidad Pablo de Olavide de Sevilla, 41013 Sevilla, Spain


Progress in the control and treatment of pain may be facilitated by a better understanding of mechanisms underlying nociceptive processing. Here we show that mice subjected to an intermittent fasting diet (IFD) display markedly reduced responses in models of thermal and visceral pain compared with mice fed ad libitum (AL). Pharmacological analyses suggest that a change in the endogenous -opioid system underlies IFD-induced analgesia. The levels of prodynorphin mRNA and -opioid receptors in the spinal cord are higher in IFD than in AL mice. Furthermore, in spinal cord nuclear protein extracts, the activity of the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), the main regulator of prodynorphin expression, is lower in IFD than in AL mice. Finally, c-Fos expression in dorsal spinal cord after noxious stimulation is significantly lower in IFD than in AL animals, indicating that dynorphin could block nociceptive information at the spinal cord. These results suggest that dietary restriction together with administration of -opioid agonists could be useful as a new therapeutic approach for pain relief.

The Journal of Neuroscience, December 3, 2003, 23(35):11120-11126

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