2001년 국제학술지(Gastrointestinal Endoscopy) 게재논문. 한의학박사 김지훈

이 논문은 경희대학교 재직시 중앙병원 내과팀과 공동연구한 논문으로서 국제적으로도 저명한 학술지에 실린 논문입니다. 무릎 아래쪽의 양릉천에 전침자극을 가함으로써 십이지장과 담낭이 연결되는 곳에 위치한 오디괄약근의 수축이 이완된 것을 환자들에게서 직접 관찰하여 보고한 논문입니다.

침술이 신체 각 기관 및 내장의 운동을 제어한다는 이론과 가설들은 많이 있었지만, 이를 객관적인 지표로서 밝힌 논문은 드물었습니다. 이 연구에서는 내시경을 통하여 오디괄약근의 압력을 재는 기구를 삽입한 후 전침자극시 시시각각 변화하는 압력을 측정해 결과를 얻었습니다. 또한 위장관내 호르몬의 변화도 함께 살펴봄으로 해서 침의 효과가 사실임을 입증하였습니다.

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Gastrointest Endosc. 2001 Feb;53(2):211-6.  DOI: 10.1067/mge.2001.112180

Electroacupuncture may relax the sphincter of Oddi in humans.

Lee SK, Kim MH, Kim HJ, Seo DS, Yoo KS, Joo YH, Min YI, Kim JH, Min BI.

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

BACKGROUND: This study was designed to evaluate the effects of electroacupuncture on sphincter of Oddi (SO) motility in humans and to associate the manometric findings with cholecystokinin (CCK) plasma levels. METHODS: Eleven patients (M:F = 5:6) with various kinds of biliary disorders were enrolled. SO motility was monitored with conventional low-compliance, continuous perfusion technique at ERCP (n = 9) or via percutaneous transhepatic cholangioscopy (n = 2). After baseline monitoring for phasic wave contractions of SO, electroacupuncture was applied at a specific acupoint GB 34. A nonspecific acupoint 5 cm away from GB 34 was selected as a control. Manometric parameters of the SO were also measured in 6 subjects during stimulation of the control acupoint. CCK plasma levels were measured during electroacupuncture stimulation. RESULTS: All manometric parameters including basal pressure, amplitude, frequency, and duration of phasic wave contractions of the SO were significantly decreased (p < 0.05) during electroacupuncture stimulation. The inhibition of SO contractility was accompanied by increased CCK plasma levels. After discontinuation of electroacupuncture stimulation, restoration of amplitude and duration to basal conditions was noted. A tendency toward return of SO basal pressure and contractile frequency to baseline was also observed. Stimulation of the control acupoint did not affect SO contractility. CONCLUSION: Electroacupuncture stimulation of acupoint GB 34 resulted in reversible inhibition of SO contraction in humans. The response of SO to electroacupuncture stimulation may be mediated by some neurohormonal mechanisms including CCK release.

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